BNC1 is required for maintaining mouse spermatogenesis
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چکیده
منابع مشابه
Mll5 Is Required for Normal Spermatogenesis
BACKGROUND Mll5 is currently a member of the Mll family of SET domain histone methyltransferase proteins but studies have also showed that it could be part of the SET3 branch of proteins. Recently, constitutive knock out animal studies have shown that Mll5 is required for proper haematopoietic stem cell differentiation, and loss of Mll5 results in synthetic lethality for genome de-methylation. ...
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From the *Division of Reproductive Biology, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland; jDepartment of Obstetrics/Gynecology, University of Colorado Health Sciences Center, Denver, Colorado; .JDepartment of Biochemistry, Washington State University, Pullman, Washington; §Department of Physiology, Laboratory of Structural Biology, Southern Illinois Univ...
متن کاملEmi2 Is Essential for Mouse Spermatogenesis.
The meiotic functions of Emi2, an inhibitor of the APC/C complex, have been best characterized in oocytes where it mediates metaphase II arrest as a component of the cytostatic factor. We generated knockout mice to determine the in vivo functions of Emi2-in particular, its functions in the testis, where Emi2 is expressed at high levels. Male and female Emi2 knockout mice are viable but sterile,...
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Dicer1, an essential component of RNA interference and the microRNA pathway, has many important roles in the morphogenesis of developing tissues. Dicer1 null mice have been reported to die at E7.5; therefore it is impossible to study its function in adult tissues. We previously reported that Dicer1-hypomorphic mice, whose Dicer1 expression was reduced to 20% in all tissues, were unexpectedly vi...
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CIB1 is a 22-kDa calcium binding, regulatory protein with approximately 50% homology to calmodulin and calcineurin B. CIB1 is widely expressed and binds to a number of effectors, such as integrin alphaIIb, PAK1, and polo-like kinases, in different tissues. However, the in vivo functions of CIB1 are not well understood. To elucidate the function of CIB1 in whole animals, we used homologous recom...
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ژورنال
عنوان ژورنال: genesis
سال: 2012
ISSN: 1526-954X
DOI: 10.1002/dvg.22014